2021 49ers Schedule

The NFL released the schedules for the 2021 NFL Season. The 49ers open the season in Detroit – Fun Fact: the last two times the 49ers opened the season in Detroit, they went onto win the Super Bowl those seasons.

The 49ers home opener will be in primetime on Sunday Night Football against the Green Bay Packers.

Outside the Packers in primetime the 49ers will have four more prime time games.