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Big Ten picks Week 6: Michigan vs. Michigan State matters again, but does Wisconsin vs. Nebraska?

Related Topics: Big Ten Conference, Wisconsin

This is not a mistake: Purdue is favored in a Big Ten game.

If that's not enough to get your attention this week, there's an interesting battle at the top of each Big Ten division.

In the East, it's Michigan-Michigan State. In the West, it's Nebraska-Wisconsin.

The spread: Penn State by 14.5.

The pick: Penn State 38, Northwestern 21

Why? Penn State's 11-game Big Ten winning streak is the second-longest in program history. Northwestern hasn't been a top 5-ranked team since 1959.