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Wife Files for Divorce

"The Hangover" star Rob Riggle got some sobering news to kick off his October ... his wife of 21 years filed for divorce.

Tiffany Riggle filed legal docs in Ventura County court to end her marriage to the comedian. She cited irreconcilable differences as the reason for the split ... this according to legal docs obtained by TMZ. They got married back on April 13, 1999, and she lists May 2, 2020 as the date of separation.

They had 2 kids together -- 16-year-old daughter Abigail and 12-year-old son George .