"How often have you suffered because of your last name?"
That's one of Tom Hanks' first-ever questions to Andrew Luck ... straight-up wondering how much the Indianapolis Colts QB has been made fun of in his life.
Don't worry ... Luck played off the awkward question well -- "It goes both ways!" -- and the two had a pretty fun first encounter Wednesday nonetheless.
Hanks and Luck were together for an event at The Children's Museum of Indianapolis ... when Hanks revealed he's a big Luck fan -- telling the QB, "I love watching you play.