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Shaquille O'Neal Shuts Down Miami Hotspot For Bday ... Happy 50th!!!

Shaquille O'Neal pulled out all the stops for his birthday on Sunday ... shutting down a Miami hotspot and throwing a HUGE party to celebrate his big 5-0.

Shaq took over Prime 112 in South Beach and partied late into the night ... and TMZ Sports has learned the bash was epic.

We're told the party featured a ton of food, Shaq-themed decorations, and plenty of star guests.

In fact, at one point during the festivities, a huge video tribute was played on a big screen ... showing a bunch of sweet messages from celebs, musicians and athletes to the Big Diesel.