Funny guy Jeff Garlin ain't laughin' when it comes to his beloved Cubs, Jake Arrieta and the COVID vaccine ... saying his favorite team will NEVER win the World Series if it keeps dodging inoculation.
The "Curb Your Enthusiasm" star -- who's a Chicago native and a huge baseball fan -- didn't hold back on the "Waddle and Silvy" show on ESPN Chicago this week ... saying a W.S. trophy won't touch Chicago unless the team gets vaxxed.
"If you don't get to 85% [fully vaccinated], I will wager everything I've got 'No' on the World Series," Garlin said.