Cam Skattebo -- the New York Giants breakout rookie running back who has electrified their offense -- was carted off the field after a big hit seemingly left his ankle facing the wrong way.
The 23-year-old fourth-round pick out of Arizona State University took the field against the Philadelphia Eagles ... and, as he was running over the middle on a passing route, when a ball came his way -- and an Eagles defender dragged him down from behind.
Check out the clip ... the Philly player puts all his weight down on CS -- and his legs get caught underneath him as he hits the turf awkwardly.