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Khloe Kardashian & Tristan Thompson Party in Puerto Vallarta with Joe Francis

Khloe Kardashian and Tristan Thompson stuck out like a sore thumb (or a green thumb?) this weekend in Mexico -- partly due to wardrobe ... not to mention the company they kept.

The two parents were partying at La Santa nightclub in Puerto Vallarta -- sans True, of course -- very early Saturday morning, where Khloe wore a bright green highlighter dress ... and Tristan stood at his usual 6'9". Safe to say, you couldn't miss 'em if you were there.

Speaking of which .