Jimmy Garoppolo’s offensive line will look a little different on Sunday Night Football. Cam Inman confirmed that Trent Williams would not be available for the San Francisco 49ers, and Jaylon Moore would start in his place. Williams was doubtful to play due to ankle and elbow injuries.
https://twitter.com/CamInman/status/1452407616198508546
Moore was a fifth-round pick of the 49ers in the 2021 NFL Draft. The rookie has played 22 offensive snaps this season, all of which came in a Week 4 loss to the Seattle Seahawks that Williams departed with an injury.
The Indianapolis Colts don’t generate much pressure on opposing quarterbacks, tied for the 11th-fewest sacks in the league.