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Dak Prescott Jokes About Crapping On Eagles, 49ers In Cancer PSA

Dak Prescott is calling on NFL fans to drop trou' and take a deuce all over their hated rival teams ... and it's all in the name of colorectal cancer awareness!!

The Dallas Cowboys quarterback released the hilarious, minute-long promo on Friday ... where he's inviting diehard football backers to join the bowel movement by getting their colons screened and supporting their allegiances at the same time.

"As a professional quarterback, I get a lot of s***," Prescott says in the video for the Colorectal Cancer Alliance's Lead From Behind campaign. "And I get it -- when you're not a fan of something, s***ing on it can make you feel good.