Cam'ron's defending O.J. Simpson's legacy ... saying people need to back off since a jury acquitted him -- and blasting Caitlyn Jenner in the process.
The rapper hopped on the "It Is What It Is" podcast Friday to discuss Simpson's legacy the day after he died, and immediately started defending the controversial figure.
Cam points out a jury found O.J. not guilty of the murders of Nicole Brown Simpson and Ron Goldman in his 1995 criminal trial .