It is very, very rare that Purdue faces an SEC team in football. The last time it happened was against Georgia in the 2004 Capital One Bowl. Against current members of the SEC Purdue is 11-7, but many of those matchups have occurred in bowl games or when the opponent was not in the SEC. In fact, of those 18 games against SEC foes, nine were against either Missouri or Texas A&M, who were not in the conference at the time of the game. That makes Purdue 4-5 all-time against the league.
Purdue has not faced an SEC team in a regular season game since playing at Vanderbilt on October 3rd, 1942.