Sheffield United were relegated to the Championship after Willian Jose's first goal for Wolves secured victory.
The visitors knew, following Newcastle's win over West Ham earlier on Saturday, that they had to avoid defeat at Molineux to delay their inevitable demotion for a few days.
But it was Wolves who edged a poor game of few chances, when they broke downfield after Enda Stevens' shot had been blocked. Adama Traore created room close to the goalline and delivered a low cross into the six-yard box, which Jose swept home.
It broke the Brazilian's Wolves duck in his 11th game for the club, having signed on loan from Real Sociedad in January.