Matt Phillips could start for West Brom after returning from a hamstring problem as a substitute in midweek.
Head coach Tony Pulis will assess the fitness of several unnamed players who are nursing minor injuries.
Oriol Romeu begins a two-match ban for Southampton as a result of accumulating 10 domestic bookings this season.
Steven Davis suffered an ankle injury in midweek and will have a fitness test, along with Manolo Gabbiadini, Ryan Bertrand and Sofiane Boufal.
MOTD COMMENTATOR'S NOTES
Mark Scott: "When Tony Pulis signed a contract extension in October, the club said establishing West Brom as a top-ten team was the aim.