Zinedine Zidane insists Real Madrid will go to Inter to win despite injuries and a run of three victories in eight games placing the Spanish champions under scrutiny.
Madrid are third in Champions League Group B, a point above the Nerazzurri, after winning the reverse fixture 3-2.
A second group win of the season would put them in a strong position to progress, but they head to San Siro without captain Sergio Ramos, midfielder Federico Valverde or striker Karim Benzema.
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Madrid are also coming off the back of a 4-1 loss to Valencia and a 1-1 draw at Villarreal in their previous two Liga matches, while they have only won twice in their past seven games in Europe.