Mauricio Pochettino's men beat Everton 4-0 last time out, while the Saints have not won in the Premier League since November
Tottenham will hope to continue a recent winning run this weekend as they take on Southampton, less than a month after beating the Saints 5-2 at Wembley.
Harry Kane broke the long-standing record for goals scored in a calendar year on Boxing Day as he netted a hat-trick in a thumping win, and Spurs have returned to that sort of form in the past two weeks.
Following a momentum-stalling draw with West Ham, Mauricio Pochettino's men have comfortably beaten Wimbledon 3-0 in the FA Cup and trounced Everton 4-0 in the Premier League.