Tottenham full-back Danny Rose is likely to be out for a month with a knee injury, joining fellow defender Jan Vertonghen on the sidelines.
Captain Hugo Lloris is expected to return in goal after illness.
Middlesbrough remain without injured pair George Friend and Gaston Ramirez, but Calum Chambers could return from a foot problem.
New signing Adlene Guedioura is available but is expected to start on the bench.
MOTD COMMENTATOR'S NOTES
Simon Brotherton: "Tottenham seemed to be coming on strong in the title race last month after impressively beating Chelsea and West Brom at White Hart Lane, but draws at both Manchester City and struggling Sunderland have taken away some of that momentum.