The Premier League's top two meet at Anfield on Sunday but there is far more at stake earlier the same day when Newcastle host Chelsea.
"This is huge for both sides in the race for the top five, and there are definitely some goals in this game," said BBC Sport football expert Chris Sutton.
"Chelsea have hit form again and it is important for them that Cole Palmer has ended his goal drought, but Newcastle are going to go for it because they are at home."
Sutton is making predictions for all 380 Premier League games this season, against a variety of guests.