Southampton defender Virgil van Dijk has been ruled out for up to three months with an ankle injury.
Manager Claude Puel is boosted by the return of Jay Rodriguez and James Ward-Prowse, while new £14m signing Manolo Gabbiadini is also in contention.
West Ham's Andre Ayew remains on Africa Cup of Nations duty but Cheikhou Kouyate has returned from the competition and is available.
Sam Byram is a doubt after injuring his hamstring against Manchester City.
MOTD COMMENTATOR'S NOTES
John Motson: "This is an interesting tussle between two teams that are in the bottom half of the table after a season blighted by inconsistency so far.