Simy Nwankwo was on target as Crotone suffered their fifth Serie A defeat of the season after bowing to a 2-1 loss against Atalanta on Saturday.
Simy reduced the deficit for Giovanni Stroppa's side two minutes after Luis Muriel grabbed his brace for the visitors in the 38th minute.
The 28-year-old has now scored three goals in six top-flight matches but Crotone's poor run continued as they are yet to win a match this campaign.
The Nigeria forward registered Crotone's only shot on target with his first-half goal and also won the highest number of free-kicks in the encounter (6), alongside his teammate Milos Vulic.