Davinson Sanchez will miss Tottenham's Champions League semi-final second leg at Ajax due to a thigh injury.
The Colombia international sustained the problem during Spurs' 1-0 Premier League loss at Bournemouth on Saturday and it leaves manager Mauricio Pochettino with a headache as his side aim to overturn a one-goal deficit at the Johan Cruijff Arena.
Jan Vertonghen suffered a nasal injury in a painful collision with team-mate Toby Alderweireld and Ajax goalkeeper Andre Onana in last week's first leg at the Tottenham Hotspur Stadium.
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Vertonghen will continue to be monitored before the match and will wear a protective face mask if he is selected.