Chris Coleman believes the hamstring injury that has ruled Aaron Ramsey out of Wales' opening 2018 World Cup qualifier on 5 September could "possibly" have been prevented.
Wales boss Coleman expected Euro 2016 star Ramsey to miss the season's start.
But the midfielder was injured in Arsenal's Premier League opener against Liverpool and will not face Moldova.
"It's disappointing he's got an injury. Could it have been prevented? Possibly, yes," said Coleman.
Ramsey's appearance in the 4-3 win over Liverpool came on 14 August with the player having last appeared for Wales in their 3-1 Euro 2016 quarter-final win over Belgium on 1 July.