The Premier League has stated match postponements for player unavailability will only be granted in 'truly exceptional' circumstances from next season.
From the start of the 2022-23 campaign, clubs will also need to prove they have 'taken all reasonable steps' to mitigate any issues to have a game rearranged.
The league has revised its guidance after a number of matches were postponed last term as coronavirus cases and isolation rules exacerbated other factors such as injury, suspension and international calls.
The most notable postponement due to last season's guidance was January's north London derby being postponed due to unavailabilities in the Arsenal squad.