Arsenal boss Mikel Arteta makes three changes from the side which drew 2-2 with Bayern Munich in the first leg of their Champions League quarter-final last Tuesday.
Oleksandr Zinchenko, Leandro Trossard and Gabriel Jesus are all recalled to the starting line-up.
Jakub Kiwior, Jorginho and Gabriel Martinelli are the players to miss out and are all named among the substitutes.
Arsenal XI: Raya, White, Saliba, Gabriel, Zinchenko, Odegaard, Trossard, Rice, Saka, Havertz, Jesus
Subs: Ramsdale, Partey, Smith Rowe, Martinelli, Nketiah, Kiwior, Tomiyasu, Jorginho, Vieira
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Unai Emery makes two changes to the Aston Villa team which beat Lille 2-1 in their Europa Conference League quarter-final first leg during the week.