Luton make three changes to the side that narrowly lost 4-3 to Arsenal on Tuesday.
Defender Tom Lockyer and midfielder Marvelous Nakamba both return following injuries with Gabriel Osho not included and Issa Kabore unable to play against his parent club.
Wing-back Ryan Giles also comes in, while midfielder Pelly Ruddock Mpanzu drops to the bench.
Luton XI: Kaminski; Mengi, Lockyer, Bell; Giles, Nakamba, Barkley, Doughty; Townsend, Brown; Adebayo.
Subs: Krul, Andersen, Berry, Morris, Chong, Mpanzu, Clark, Lokonga, Johnson.
Manchester City make four changes with the big news being the absence of Erling Haaland in the Citizens' squad.