The standout fixture after the international break sees Premier League leaders Arsenal take on arch-rivals Tottenham at the Emirates Stadium.
It's been 10 months since we last had a north London derby, which saw Arsenal claim the spoils with a 2-1 win.
That win continued the Gunners' dominance in this fixture's recent history - having won five of the last six and drawing the other.
Arsenal are going to be sweating over some injury concerns with Gabriel, Martin Odegaard, Victor Gyokeres all touch-and-go for the derby.
Spurs have their own lengthy list of doubts too with their number in the double digits.