Manchester United defender Lisandro Martinez is expected to be out for two to three months with a foot injury.
He returned to action at the start of this season but United say he will be sidelined again because of "an aggravation" to the injury.
The club said Martinez "experienced the setback in our Premier League game against Arsenal earlier this month".
"It has now been determined that he needs a period on the sidelines for recovery and rehabilitation.
"Assessment is ongoing to determine next steps."
Martinez played against Wolves, Tottenham and Nottingham Forest before facing Arsenal in a 3-1 defeat by the Gunners on 3 September.