Liverpool and Manchester City women's and youth teams are set to use special mouthguards in training to assess the impact of heading the ball.
Already used in rugby, the mouthguards are able to collect data in real time and show how impacts affect the brain.
It will form part of a Premier League research project after concerns about the long-term dangers of heading.
In 2019, a study found professional footballers more likely to suffer from neurodegenerative brain disease.
The Premier League wants the research to be completed in months after accusations that football has been slow to act.