It is a Merseyside derby that will see two clubs in crisis situations come up against each other.
Jurgen Klopp's Liverpool side go into Monday's Premier League meeting at Anfield in freefall. They are without a victory in their past four league games and suffered a humbling defeat at Wolves in their last game.
Sean Dyche, meanwhile, enjoyed a dream start as Everton manager last weekend with victory over leaders Arsenal but his side remains in the relegation zone.
BBC Sport takes a look at the key issues surrounding the fixture.