Ghana U23 attacker Joseph Paintsil was among the scorers as Genk handed Waasland-Beveren a 4-0 defeat in the Belgian top-flight on Saturday.
The winger's goal and a Mbwana Samatta hat-trick were all the Blue-White needed to claim all three points in the matchday four fixture away at Freethiel Stadium.
The win places Felice Mazzu's men seventh on the league table, eight places above second-from-bottom Waasland-Beveren.
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Paintsil gave Genk the lead in the 21st minute, sending a glancing header into the net after connecting to a Junya Ito cross.
Bryan Heynen then set up Samatta to make it 2-0 in the 53rd minute.