As of this writing, there are eight NFL players who have been confirmed as having chosen to opt out of participation during the 2020 season. There are others who have been reported as weighing this decision heavily, as Marcus Cannon of the New England Patriots had, who it was reported late last night ultimately decided to opt out. Cannon battled cancer while he was in college.
The most high-profile opt-out so far is Kansas City Chiefs guard Laurent Duvernay-Tardif, who almost immediately announced his decision as soon as the opt-out process was finalized. Throughout the offseason, the medical school graduate has been contributing as an orderly in a long-term care facility.