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Multiple Steelers Defenders Injured To Open Colts Game.

Pittsburgh Steelers CB Darius Slay was injured on the team’s first defensive possession in the team’s Week 9 game against the Indianapolis Colts. Slay landed hard and was tended to by trainers on the field. Per ESPN’s Brooke Pryor, Slay was up and walking off and the injury appeared to be a hand/wrist injury.

He headed to the locker room after leaving with the injury, per Pryor.

Slay goes straight from the medical tent to the locker room still holding his hand.

— Brooke Pryor (@bepryor) November 2, 2025

Earlier in the drive, OLB Alex Highsmith, who had an early run stop to bring down RB Jonathan Taylor in the backfield, limped off the field ahead of a third down and the CBS broadcast showed him in visible pain.