It used to be commonplace for teams to take running backs in the first round of the draft. Now, in many years, you might be lucky to see more than one go before the second day of the draft. The 2021 NFL Draft in particular is pretty clearly defined as having an upper echelon consisting of three running backs: Najee Harris, Travis Etienne, and Javonte Williams.
Whether or not all three of them end up being taken in the first round remains to be see, but they almost certainly figure to be the first three backs who are drafted.