It's going to take more than just a hopeful jump-start from quarterback Kedon Slovis, or another record rushing performance from Israel Abanikanda to put Pitt in a position to earn a victory out of its open week.
It's going to take the performances of the five men which line up in front of them -- from within a unit which is thin due to injury.
On the other side of the ball, Pitt's defense line has its most unique challenge of the season on tap, with the electrifying, dynamic, and at-times unstoppable Malik Cunningham under center for Louisville (3-3, 1-3 ACC).