Penn State at Ohio State final odds and predictions

Ohio State v. Penn State | Scott Taetsch/GettyImagesPenn State football and No. 1 Ohio State came off Week 9 byes ahead of their matchup on Saturday. The Nittany Lions (3-4, 0-4 Big Ten) have yet to win a Big Ten game in 2025 and seek to snap their four-game losing streak against their toughest opponent of the season. The Buckeyes (7-0, 4-0 Big Ten) have yet to lose a game in 2025 and aren't looking to do so anytime soon. Kickoff at Ohio Stadium is at 12 p.m. ET and the game is the featured contest on FOX's Big Noon Kickoff.

The Week 10 battle is interim head coach Terry Smith's and second-string, now starting quarterback Ethan Grunkemeyer's second game taking on their newfound roles. Penn…