Since becoming conference rivals Washington State holds the edge on Colorado, winning three of five meetings straight up and going 3-2 against the spread. The Cougars, questing for their first-ever appearance in the Pac-12 championship game, battle the Buffaloes on Saturday afternoon in Boulder.
College football point spread: The Cougars opened as four-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 34.7-27.5 Cougars (College football picks on every game)
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