Stanford won six of eight meetings with USC into last season, but the Trojans beat the Cardinal twice last year, including in the Pac-12 Championship Game. In a huge early-season conference contest that might be a preview of this year's Pac-12 championship Southern Cal takes on Stanford Saturday night out on the Farm.
College football point spread: The Cardinal opened as five-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 34.6-28.2 Trojans (College football picks on every game)
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