Single-elimination game. Winners advance to the Conference Semifinals.
| Wednesday, October 26 | |||
|---|---|---|---|
| 7:30 PM PM ET | Toronto FC vs Philadelphia Union | TOR 3 - PHI 1 | Highlights & recap |
| 10:30 PM ET | LA Galaxy vs Real Salt Lake | LA 3 - RSL 1 | Highlights & recap |
| Thursday, October 27 | |||
| 7:30 PM ET | D. |