No. 5 Oklahoma Sooners (2-0) at Iowa State Cyclones (0-1)
When: 9 a.m. PT Saturday, Sept. 15
Where: Jack Trice Stadium | Ames, Iowa
Latest line: Oklahoma by 18.5
Over/under: 54.5
Why to watch: Sure, the Sooners are heavy favorites and boast offensive firepower with Kyler Murray running the show, but Iowa State upset then-No. 3 Oklahoma in Norman last season. The Cyclones also beat No. 4 TCU at home last year and lost to No. 15 Oklahoma State by a touchdown.
Florida State Seminoles (1-1) at Syracuse Orange (2-0)
When: 9 a.