Though conference rivals for the past 12 years, Oregon and Colorado did not first play in football until after WWII. That game was a big victory for the Ducks, 42-14 at home on October 15, 1949. The Buffaloes avenged the prior loss 21-7 when the Ducks made the return trip to Boulder on November 18, 1950. The programs played further home-and-home series in ‘50s, ‘60s, and ‘70s. Colorado swept Oregon in ‘67 and ‘68, but the other games were evenly split.
The teams then played back to back home and home series from 1984 to 1987. The Ducks beat the Buffaloes twice in Eugene but had lost in Boulder.