The Cowboys fought hard but their Big 12 losing streak will extend into its third season.
Oklahoma State fell to Iowa State 20-13, despite a resilient effort on Senior Day.
The Cowboys pulled within one score three times but turnovers and missed opportunities kept them from getting over the hump.
The Cyclones took a 10-0 lead before the Cowboys were able to get on the board and the Cowboys remained within 10 the entire game.
After the Cowboys stalled on their first three drives, Zane Flores hit his stride in the second quarter, leading them on a 14-play, 80-yard touchdown drive.