Final odds and predictions for Ohio State football vs Purdue

The Ohio State football team is a massive favorite over Purdue. Will they win the game?

Ohio State Buckeyes linebacker Arvell Reese (8) hits Penn State Nittany Lions wide receiver Devonte Ross (5) beside cornerback Lorenzo Styles Jr. (3) during the NCAA football game at Ohio Stadium in Columbus on Nov. 1, 2025. | Adam Cairns/Columbus Dispatch / USA TODAY NETWORK via Imagn ImagesThe Ohio State football team has a history of getting upset in West Lafayette by an unranked Purdue team. In 2018, it was a house of horrors for the Buckeyes. They went into that game as the second-ranked team in the country and got smacked around by the underdog Boilermakers.

Ryan Day was on staff when that game was…