Ohio State's only loss this season still resonated throughout the week. Too much was at stake in terms of their national championship chances.
Although extremely unlikely to repeat itself, the 2007 season showed it's not impossible for the Buckeyes to climb back into the title picture. No other win over the Wolverines on this list was nearly as rewarding, so not much there for precedent's sake.
OSU typically heads into Michigan week with a bit of confidence, having recently won three-years straight and 11 times this century the Saturday prior.
2011: Loss to Penn State, Loss to Michigan
Arguably the worst team on this list lost the last four games of its season including the bowl game.