Marcus Semien's two-run double in the third was the only damage done to Paxton, who allowed just two hits and two runs in improving to 7-3 with a 3.21 ERA. Paxton equaled his season high with nine strikeouts.
Manaea (7-5, 3.76 ERA) countered with seven innings of three-run ball as he gave up eight hits, including Cruz's second RBI single of the game in the third, followed by the go-ahead sacrifice fly by Kyle Seager.
Cruz broke the game open with a three-run blast off reliever Liam Hendriks in the eighth, with his five RBIs moving him past Yankees rookie Aaron Judge for the American League lead with 68.