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Notre Dame Football: Betting Lines for Louisville Game Plus Heisman, Championship Odds

The Notre Dame Fighting Irish are 20 point favorites in their game against the Louisville Cardinals Monday at Cardinal Stadium, according to oddsmakers.

The over/under — or “the predicted number of points oddsmakers believe will be scored in the game by both teams combined” — is 54 12 points. That suggests a 37-18 Irish victory.

The OddsShark computer is predicting a far more lopsided game, with the Irish prevailing 48-7. If that were the final, bettors holding slips for the Irish on the moneyline and against the spread would cash, as would the over.