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Notre Dame Fighting Irish VS Louisville Cardinals: Football Betting Lines

This is getting a little crazy. The Notre Dame Fighting Irish will host the Louisville Cardinals on Saturday afternoon, and the Vegas predictions involve the Irish as double digit favorites in yet another game. In fact, this now if the 4th game out of 4 where the Irish go into it as double digit favorites. We’ll get into the specifics in a bit, but this spread is actually the smallest point spread of the four games the Irish have had this season.

ND vs Louisville Betting Lines

The Cardinals come into Notre Dame Stadium for the first time (and their only time) in 2014.