The Irish strength of schedule took a small hit, as ND's opponents struggled during week 4.
| Irish Schedule | Opponent | Score | Season Record |
| Texas Longhorns | Oklahoma State Cowboys | L 30-27 | 1-3 |
| Virginia Cavaliers | Boise State Broncos | L 56-14 | 1-3 |
| Georgia Tech Yellow Jackets | @Duke Blue Devils | L 34-20 | 2-2 |
| UMass Minutemen | @Notre Dame Fighting Irish | L 62-27 | 0-3 |
| Clemson Tigers | Open Date | N/A | 3-0 |
| Navy Midshipmen | @UConn Huskies | W 28-18 | 3-0 |
| Southern Cal Trojans | @Arizona State Sun Devils | W 42-14 | 3-1 |
| Temple Owls | Open Date | N/A | 3-0 |
| Pittsburgh Panthers | Open Date | N/A | 2-1 |
| Wake Forest Demon Deacons | Indiana Hoosiers | L 31-24 | 2-2 |
| Boston College Eagles | Northern Illinois Huskies | W 17-14 | 3-1 |
| Stanford Cardinal | @Oregon State Beavers | W 42-24 | 3-1 |
Irish Opponent Week 4 Record: 4-5 Irish Opponent Season Record: 26-17
Irish opponents had a tough week four going just 4-5, but none had a more frustrating loss than Texas.