Full-back Romain Perraud, who missed Southampton's win over Everton after testing positive for Covid-19, is available.
Norwich City goalkeeper Tim Krul has recovered from a shoulder injury and could return to the squad on Friday.
Jacob Sorensen and Lukas Rupp are back in training, leaving Adam Idah and Andrew Omobamidele as the only injured players.
LAWRO'S PREDICTION
Norwich are back at the bottom of the table but I watched the Canaries when they lost at Liverpool last weekend and I was impressed.
Dean Smith's side showed lots of spirit and carried the fight to Liverpool, which doesn't always happen.