Swansea City Under-21s face a 626-mile round trip to face Norwich City U21s in the last 32 of the Checkatrade Trophy.
They play one of three all under-21 ties along with Wolves v Sunderland and Southampton v Reading, with eight under-21 sides left in the competition.
Last year's runners-up Oxford travel to Southend, while two-time winners Carlisle host Mansfield Town.
Cambridge United have a 320-mile round trip to Bradford City in the Northern Section of the competition.
The competition has been revamped by the English Football League this season to include 16 Category One academy sides, but has been characterised by low attendances.