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Sources: San Francisco 49ers QB Jimmy Garoppolo, TE George Kittle to miss multiple weeks

SANTA CLARA, Calif. -- In a season full of seemingly non-stop, devastating injury news, the San Francisco 49ers might have taken their two biggest hits Monday when sources told ESPN's Adam Schefter that quarterback Jimmy Garoppolo and tight end George Kittle are expected to miss extended time.

For Garoppolo, the aggravation of his high right ankle sprain that took place in Sunday's loss to the Seattle Seahawks is expected to keep him out for a minimum of six weeks and possibly longer if the ankle requires surgery, a source told Schefter.